The oldest surviving Buddhist manuscripts are the Gandhāran Buddhist texts, reported to have been found in or around Haḍḍa near Jalalabad in eastern Afghanistan and now preserved in the British Library. They are written in the Gāndhārī language using the Kharosthi script on twenty-seven birch bark manuscripts and date from the first century BCE to the third century CE.
Source: Wikipedia
In 1455, Gutenberg completed copies of a beautifully executed folio Bible (Biblia Sacra), with 42 lines on each page. Copies sold for 30 florins each, which was roughly three years' wages for an average clerk. Nonetheless, it was significantly cheaper than a manuscript Bible that could take a single scribe over a year to prepare. After printing, some copies were rubricated or hand-illuminated in the same elegant way as manuscript Bibles from the same period. 48 substantially complete copies are known to survive, including two at the British Library that can be viewed and compared online. The text lacks modern features such as pagination, indentations, and paragraph breaks.
Source: Wikipedia